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Autoimmune Polyendocrinopathy
The term Autoimmune Polyendocrinopathy (also known as Schmidt’s
syndrome) refers to an autoimmune disease affecting multiple endocrine
organs like pancreas, adrenal gland or thyroid gland.
ADDISON’S DISEASE
Indirect immmunofluorescence assay is the conventional method for the
determination of anti-adrenal cortex antibodies (AACA).
The presence of cytoplasmic adrenal antibodies (AACA) is strongly
indicative of Addison’s disease, an uncommon disorder due to a
deficiency of adrenocortical hormones. Almost all individuals with a
primary amenorrhea and Addison’s disease have detectable cytoplasmic
adrenal antibodies. These autoantibodies are useful markers for the
prediction of the development of Addison’s disease. Results obtained
in a comparative study do not show significant systematic differences
compared to an anti-21 hydroxylase antibodies radioimmunoassay.
ANTI-ADRENAL CORTEX ANTIBODIES (AACA)
44574
IFA Slide Box, 12 slides x 4 wells
Monkey Adrenal
AUTOIMMUNE THYROIDITIS
Antibodies to human thyroid peroxidase (Anti-TPO) are present typically
in patients with Hashimoto’s disease (90-100% of the patients),
primary hypothyroidism or myxedema (80%), Grave’s disease (50-
80%), type I diabetes mellitus (40%) and pregnant women (14%). They
are also detected, together with anti-Tg antibodies, in other diseases:
endemic goiter, subacute thyroiditis, Addison’s disease, polyendocrine
autoimmunopathies and in members of families prone to organ specific
autoimmunity. Nevertheless, they can be also present in a 5-20% of
healthy individuals.
Anti Thyroglobulin (Anti-Tg) antibodies are present typically in patients
with Hashimoto’s disease (80-90% of the patients), primary myxedema
(80%), Grave’s disease (50-70%), type I diabetes mellitus (40%) and
pregnant women (14%). Although elevated anti-Tg antibodies are
common in differentiated cancer, but they have no clinical value. They
are also detected, together with anti-TPO antibodies, in other diseases:
endemic goitrous, subacute thyroiditis, Addison’s disease, polyendocrine
autoimmunopathies and in members of families prone to organ specific
autoimmunity. Nevertheless, they can be also present in a 5-20% of
healthy individuals.
ANTI-THYROID ANTIBODIES
44550
IFA – Complete kit, 12 slides x 4 wells
44551
IFA – Slide Box, 12 slides x 4 wells
Monkey Thyroid
ANTI-THYROID PEROXIDASE ANTIBODIES (TPO)
44795
ELISA kit, 96 T.
Recombinant human antigen
ANTI-THYROGLOBULIN ANTIBODIES (Tg)
44796
ELISA kit, 96 T.
Highly purified human antigen
DIABETES MELLITUS
Indirect immmunofluorescence assay is the conventional method for the
determination of anti- islet cell antibodies (AICA). Islet cells antibodies
(AICA) are strongly associated with insulin-dependent diabetes mellitus.
Results obtained in a comparative study with anti-GAD and anti-IA2
antibodies detection tests showed a good concordance.
INSULIN
Autoantibodies against insulin are present in patients with type I diabetes
along with other autoantibodies (mainly, anti-glutamic acid decarboxylase
65, anti-tyrosine phosphatase IA 2 and cytoplasmic islet cell antibodies),
but anti-insulin antibodies are usually the first to appear. Anti-insulin
antibodies are detectable in 50-70% of children at the onset of type I
diabetes and only 20-30% in older patients.
ANTI-ISLET CELLS ANTIBODIES
44609
IFA – Complete kit, 12 slides x 4 wells
Controls not included
44572
IFA – Slide Box, 12 slides x 4 wells
Monkey Pancreas
ANTI-INSULIN ANTIBODIES
44873
ELISA KIT 96 T
Mixture of recombinant and purified insulin
Anti-adrenal cortex antibodies
Monkey adrenal cortex
Anti-thyroid peroxidase antibodies
Monkey thyroid
Anti-islet cell antibodies
Monkey pancreas
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