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Bullous Diseases
ASA
Anti-skin antibodies directed to the intercellular space of the stratified
squamous epithelia are characteristic of pemphigus vulgaris, pemphigus
foliaceus and paraneoplastic pemphigus. Although results obtained by
indirect immunofluorescence are very specific for pemphigus, the type of
pemphigus cannot be differentiated by indirect immunofluorescence. In a
small percentage of patients with pemphigus, no circulating antibodies can
be demonstrated, since the antibody already bound to the patient’s skin.
Anti-basement membrane antibodies are found in 70% of patients with
bullous pemphigoid by using indirect immunofluorescence, in 20-25%
of patients with herpes gestationis and in 10% of patients with cicatricial
pemphigoid.
ANTI-SKIN ANTIBODIES (ASA)
44560
IFA – Complete kit, 12 slides x 4 wells
Controls not included
44561
IFA – Slide Box, 12 slides x 4 wells
Monkey Esophagus
Anti-skin antibodies.
Basement membrane Monkey esophagus
Anti-skin antibodies.
Intercellular substance Monkey esophagus
9
Miasthenia Gravis
44649
ANTI-STRIATED MUSCLE ANTIBODIES (AStMA)
IFA – Slide Box, 12 slides x 4 wells
Rat striated muscle
AStMA
Anti-striated muscle antibodies react against the antigens localized in the
I,A and Z bands of the muscle fiber, which act as the contractile elements
of the skeletal muscle. Its presence has been described in 30-60% of
patients with myasthenia gravis. The frequency of these antibodies in MG
patients suffering from thymoma can reach up to 80-100%, depending on
the study, becoming a valuable thymoma serological marker especially
in patients with onset MG younger than 45 years. It is more predictive of
thymoma when accompanied by a muscle acetylcholine receptor (AChR)
modulating antibody. Its presence is also useful as a screening test for
MG in older patients, especially when tests for muscle AChR antibodies
are negative.
These antibodies mainly react with the intracellular skeletal muscle
protein titin and the ryanodine receptor.
Anti-Striated Muscle Antibodies
Rat striated muscle