6 / 20
Anti-phospholipid Syndrome
Although first described in patients with SLE, anti-phospholipid antibodies
(ACA) are present in patients with antiphospholipid syndrome. ACA react
with negatively charged phospholipids, including cardiolipin.
CARDIOLIPIN
Although first described in patients with systemic lupus erythematosus,
ACA are present in patients with antiphospholipid syndrome (APS). Anti-
phospholipid antibodies react with negatively charged phospholipids,
including cardiolipin. High levels of anti-cardiolipin IgG or IgM antibodies
in serum or plasma are associated with an increased risk of thrombosis
and pulmonary embolism, and an important risk factor for stroke and
recurrent fetal loss. Anti-cardiolipin antibodies titers may decrease during
treatment with corticosteroids.
β
2-GLYCOPROTEIN I
Anti-
β
2-GP1 antibodies are present in the IgG, IgM or IgA isotypes. IgG
anti-
β
2-GP1 antibodies are more specific than IgM, and are found in
progressive stages of manifested autoimmune disorders. IgM anti-
β
2-
GP1 antibodies are useful in the diagnosis of early stages of autoimmune
disorders. IgA anti-
β
2-GP1 antibodies may have a pathogenic role
in thrombosis and APS5. Determination of anti-
β
2-GP1 antibodies is
indicated for SLE, thrombosis, thrombocytopenia, recurrent abortion and
intrauterine death.
ANNEXIN V
Autoantibodies against annexin V are present in high levels in APS
patients, but also can be found, especially the IgG isotype, in serum
samples of patients with SLE, rheumatoid arthritis, and recurrent fetal
loss and pre-eclampsia.
ANTI-CARDIOLIPIN ANTIBODIES (ACA-IgG/IgM)
44780
ELISA 96 T
Highly purified antigen
ANTI-PHOSPHOLIPID ANTIBODIES IgA/IgM (APLA)
44867
ELISA 96 T
Mixture of cardiolipin, phosphatidyl serine,
phosphatidyl inositol, phosphatidic acid and
β2
-Glycoprotein 1
ANTI-
β
2-GLYCOPROTEIN I ANTIBODIES IgG/IgM (
β
2-GP1)
44868
ELISA 96 T.
Highly purified antigen
ANTI-ANNEXIN V ANTIBODIES IgG/IgM (ANX)
44869
ELISA 96 T.
Highly purified antigen
4