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Vasculitis is a group of diseases featuring inflammation of the wall of
blood vessels due to leukocyte migration and resultant damage. While
most vasculitides are rare, they generally affect several organ systems
and can cause severe disability.
PR-3
There is a strong association between anti-PR3 antibodies and Wegener’s
granulomatosis. Specificity has been found of 95-98%. Sensitivity
depends on the phase and the activity of the disease, and has been
found around 90% for expanded Wegener’s granulomatosis (i.e. with
necrotizing glomerulonephritis, systemic vasculitis and granulomatous
inflammation of the respiratory tract), and around 75% for limited
Wegener’s granulomatosis (i.e. without renal involvement).
MPO
High levels of anti-MPO antibodies are found in 65% of patients with
idiopathic necrotizing glomerulonephritis, 60% of patients with Churg-
Strauss syndrome, 30-40% of patients with Goodpasture’s syndrome and
10% of patients with Wegener’s granulomatosis. Specificity for systemic
vasculitis and idiopathic necrotizing glomerulonephritis goes up to 95%.
ANTI-NEUTROPHIL CYTOPLASMANTIBODIES (ANCA)
44850
Ethanol fixed, IFA Complete kit, 4 slides x 6 wells
44851
Ethanol fixed, IFA Complete kit ,10 slides x 6 wells
44852
Ethanol fixed, IFA Slide Box ,10 slides x 6 wells
44878
Formalin fixed, IFA Slide Box, 10 slides x 6 wells
44898
Formalin fixed, IFA Complete kit, 10 slides x 6 wells
ANTI-PR3 ANTIBODIES (C-ANCA)
44791
ELISA 96 T
Purified human antigen
ANTI-MPO ANTIBODIES (P-ANCA)
44790
ELISA 96 T
Purified human antigen
Vasculitis
Glomerular basement membrane antibodies
Monkey kidney
GBM
Indirect immmunofluorescence assay is the conventional method for
the determination of anti-glomerular basement membrane antibodies
(GBMA). Antibodies to GBM are present in patients with Goodpasture’s
syndrome. The disease presents a progressive glomerulonephritis with or
without massive pulmonary hemorrhage. The finding of GBMA confirms
a diagnosis of a life threatening disease that causes loss of kidney, and
indicates a grave prognosis. Results obtained in a comparative study do
not show significant systematic differences compared to an ELISA for
anti-type IV collagen alpha chain antibodies.
ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODIES
(GBMA)
44588
IFA – Slide box, 12 slides x 4 wells
Monkey Kidney
44870
ELISA kit 96 T
Highly purified antigen
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