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AUTOIMMUNE HEPATITIS
Autoimmune hepatitis (AIH) is a progressive inflammation of liver that has
been identified by a number of different names, including autoimmune
chronic active hepatitis (CAH), idiopathic chronic active hepatitis,
and lupoid hepatitis. There are three types of autoimmune
hepatitis (AIH), each of them has a different pattern of autoantibodies.
Type 1: Is the more frequent type of AIH. ANA and/or ASMA and
sometimes ANCA are positive.
Type 2: Is more frequent in children. LKM-1 (antibodies against a
component of cytochrome P-450, CYP 2D6) are positive.
ANCA are always negative.
Type 3: SLA (Soluble Liver Antigen, a UGA repressor tRNA-associated
protein) is positive.
AMA
Granular fluorescence of mitochondria in the cytoplasm of renal tubular
cells. The presence of anti-mitochondrial antibodies is associated with
primary biliary cirrhosis (over than 95% of patients).
M2
Nine mitochondrial antibody subtypes have been described up to now,
but only four are related with primary biliary cirrhosis (PBC): M2, M4,
M8 and M9. However, it is well established that only anti-M2 antibodies
are specific for PBC. These antibodies can be detected years, even
decades, before the onset of clinical and histological symptoms. Due to
its high sensitivity and specificity, determination of anti-M2 by ELISA is
recommended for differential diagnostic of the PBC.
ASMA
Staining of the muscularis mucosae, the muscle layers of blood vessels
and the interglandular fibers, in rat stomach. Anti-smooth muscle
antibodies are the standard diagnostic marker of autoimmune hepatitis.
Anti-actin antibodies, a subgroup of smooth muscle antibodies, are
found in the sera of 52-85% of patients with autoimmune chronic active
hepatitis and 22% of patients with primary biliary cirrhosis. Its presence
in other autoimmune diseases as cholangyopathy reflects overlapping
features of those diseases.
LKM
Anti-LKM type I antibodies are considered as markers of autoimmune
hepatitis type II.
PERNICIOUS ANEMIA
APCA
Reticular intracellular staining of parietal cells of rat gastric mucosa.
Antibodies to gastric parietal cells are found in 90% of patients with
pernicious anemia, usually associated with other tissue specific
autoimmune diseases.
ANTI-SMOOTH MUSCLE ANTIBODIES (ASMA)
44520
IFA – Complete kit, 12 slides x 4 wells
44524
IFA – Complete kit, 12 slides x 8 wells
44521
IFA – Slide Box, 12 slides x 4 wells
44525
IFA – Slide Box, 12 slides x 8 wells
Rat Stomach
ANTI-MITOCHONDRIAL ANTIBODIES (AMA)
44510
IFA – Complete kit, 12 slides x 4 wells
44514
IFA – Complete kit, 12 slides x 8 wells
44511
IFA – Slide Box, 12 slides x 4 wells
44515
IFA – Slide Box, 12 slides x 8 wells
Rat Kidney
AUTOANTIBODIES RL/RK/RS (ANA-AMA-ASMA-APCA-LKM)
44558
IFA – Complete kit, 12 slides x 4 wells
44648
IFA – Complete kit, 12 slides x 8 wells
44570
IFA – Slide Box, 12 slides x 4 wells
44639
IFA – Slide Box, 12 slides x 8 wells
Rat Liver / Kidney / Stomach
AUTOANTIBODIES MsK/MsS (AMA – ASMA – APCA)
44518
IFA – Slide Box, 12 slides x 4 wells
Mouse Kidney/Stomach,
AUTOANTIBODIES MsL/MsK/MsS
(ANA – AMA – ASMA – APCA – LKM)
44826
IFA – Slide Box, 12 slides x 4 wells
44827
IFA – Slide Box, 12 slides x 8 wells
Mouse Liver/Kidney/Stomach
ANTI-M2 ANTIBODIES (M2)
44871
ELISA kit 96 T
Highly purified mitochondrial M2 subtype antigen
7
X-ANCA
Among the IBD, X-ANCA are more common in ulcerative colitis (44.1%)
than in Chron´s disease (8.1%) and the combination of ANCA methanol
fixed test by IIF and ASCA test by IIF or ELISA often becomes an aid for
their differentiation. X-ANCA pattern (or atypical P-ANCA) is the result of
the autoantibody binding to proteins such as lactoferrin, elastase, BPI,
cathepsin G among others
ANTI-NEUTROPHIL CYTOPLASM ANTIBODIES (ANCA)
44895
Methanol fixed, IFA Slide Box, 10 slides x 6 wells
ANTI-BPI ANTIBODIES
44905
ELISA 96 T / Purified human antigen
ANTI CATHEPSIN G ANTIBODIES
44906
ELISA 96 T / Purified human antigen
ANTI-ELASTASE ANTIBODIES
44907
ELISA 96 T / Purified human antigen
ANTI-LACTOFERRIN ANTIBODIES
44908
ELISA 96 T / Purified human antigen
ANTI-LYSOZYME ANTIBODIES
44909
ELISA 96 T / Purified human antigen